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	<title>Carin Smit C/Clinical Metal Toxicologist &#187; Nutrition</title>
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	<description>C/Clinical Metal Toxicologist</description>
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		<title>Nutrient Support Against A Common Silent Threat</title>
		<link>http://carinsmit.co.za/blog/nutrition/nutrient-support-against-a-common-silent-threat/</link>
		<comments>http://carinsmit.co.za/blog/nutrition/nutrient-support-against-a-common-silent-threat/#comments</comments>
		<pubDate>Fri, 05 Nov 2010 05:43:11 +0000</pubDate>
		<dc:creator>mafia</dc:creator>
				<category><![CDATA[Nutrition]]></category>

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		<description><![CDATA[It could take the form of aching, stiff joints… or a nagging, sore back. It could also take the form of embarrassing gut trouble. That&#8217;s why any doctor will tell you that keeping the inflammatory process in balance is, perhaps, the most essential cornerstone of healthy aging.
Unfortunately, certain unavoidable factors—like stress, sleep loss or air [...]]]></description>
			<content:encoded><![CDATA[<p>It could take the form of aching, stiff joints… or a nagging, sore back. It could also take the form of embarrassing gut trouble. That&#8217;s why any doctor will tell you that keeping the inflammatory process in balance is, perhaps, the most essential cornerstone of healthy aging.</p>
<p>Unfortunately, certain unavoidable factors—like stress, sleep loss or air pollution—may be sabotaging your best efforts at balancing your body&#8217;s normal inflammatory responses.<sup>1-4</sup> The truth is, you need all the help you can get in this ongoing fight. And luckily, research shows that just a few key botanicals can offer you just that—delivering multi-pronged support for a long, healthy and pain-free life.</p>
<p>For example, research shows that ginger acts against a wide range of pro-inflammatory cytokines—including IL-1beta, IL-2, IL-12, TNF-alpha and interferon (IFN)-gamma.<sup>5</sup> The flavonoid luteolin delivers similar benefits, with animal studies showing that oral supplementation inhibits TNF-alpha production and reduces swelling—while preparations of stinging nettle (Urtica dioica) have been linked to as much as a 99 percent reduction of several inflammatory cytokines, including IL-1 beta and TNF-alpha.<sup>6-11</sup></p>
<p>Holy basil leaf helps to suppress the production of the enzymes COX-2 and LOX-5—the latter is responsible for generating the leukotrienes linked to unhealthy cellular processes, as well as less than optimal lung, joint, skin and colon health. A special extract of bowellic acids (called 5-Loxin™) also is a powerful LOX-5 inhibitor.<sup>12-14</sup> Meanwhile, the natural compounds tetrandrine and fangchinoline (both found in Stephania tetrandra) have been shown to suppress the activity of IL-6—one of the main causes of elevated C-reactive protein, a marker of inflammation, in the blood—by up to 86 percent.<sup>15</sup></p>
<p>The green tea polyphenol EGCG is also well known to support a healthy immune system, which is why this powerful antioxidant is included with all the botanicals mentioned above as part of VRP&#8217;s all-natural daily formula, Advanced Inflammation Control.<sup>16</sup></p>
<p>The right nutrients can also offer critical support for joint comfort. The amino acid DL-phenylalanine, for example, promotes joint comfort by blocking the breakdown of enkephalins, your body&#8217;s natural pain reducers—in fact, studies reveal as much as a 75 percent positive response rate to D,L-phenylalanine among those supplementing with it.<sup>17</sup> Turmeric extract containing 95% cucuminoids, on the other hand, has been shown to modulate COX, LOX and iNOS; providing balanced function of each of these enzymes, which is important when supporting the body&#8217;s normal inflammatory responses.<sup>18-19</sup></p>
<p>Clinical trials also show that Boswellia serrata supplementation delivers improvements in knee comfort, flexibility and walking distance—while the natural enzyme Nattokinase aids in breaking down fibrin deposits that can interfere with healthy circulation.<sup>20-21</sup> You&#8217;ll find all of these beneficial nutraceuticals combined in VRP&#8217;s daily formula Back in Action™.</p>
<p>Finally, enzymes like serrapeptase, papain, bromelain, amylase and lipase offer a comprehensive, natural way to support the body&#8217;s normal inflammatory mechanisms, and deliver improvements in a number of measures—including swelling, normal clotting processes, circulation plus increasing nutrient and oxygen supply—to promote rapid and greater comfort.<sup>22</sup> As part of the comprehensive enzyme blend, called UniZyme™, VRP has combined all of these proteolytic enzymes with the botanicals amla and rutin—which help to enhance connective tissue repair and renewal.<sup>23-26</sup></p>
<hr />
<h2>References:</h2>
<ol>
<li>den Hartigh LJ, Lamé MW, Ham W, Kleeman MJ, Tablin F, Wilson DW. Endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from Fresno, California initiate human monocyte inflammatory responses mediated by reactive oxygen species. Toxicol In Vitro. 2010 Aug 27. Published Online Ahead of Print.</li>
<li>Puustinen PJ, Koponen H, Kautiainen H, Mäntyselkä P, Vanhala M. Psychological distress and C-reactive protein: do health behaviours and pathophysiological factors modify the association? Eur Arch Psychiatry Clin Neurosci. 2010 Aug 14. Published Online Ahead of Print.</li>
<li>Drager LF, Lopes HF, Maki-Nunes C, Trombetta IC, Toschi-Dias E, Alves MJ, Fraga RF, Jun JC, Negrão CE, Krieger EM, Polotsky VY, Lorenzi-Filho G. The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome. PLoS One. 2010 Aug 11;5(8):e12065.</li>
<li>Irwin MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC, Martinez-Maza O, Cole S. Sleep loss activates cellular inflammatory signaling. Biol Psychiatry. 2008 Sep 15;64(6):538-40. Epub 2008 Jun 17.</li>
<li>Tripathi S, Bruch D, Kittur DS. Ginger extract inhibits LPS induced macrophage activation and function. BMC Complement Altern Med. 2008 Jan 3;8:1.</li>
<li>Kim JA, Kim DK, Kang OH, et al. Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells. Int Immunopharmacol. 2005; 5:209-17.</li>
<li>Kotanidou A, Xagorari A, Bagli E, et al. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med. 2002;165:818-23.</li>
<li>Ueda H, et al. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-[alpha] production. Biosci Biotechnol Biochem. 2004;68:119-25.</li>
<li>Klingelhoefer S, Obertreis B, Quast S, et al. Antirheumatic effect of IDS23, a stinging nettle leaf extract, on in vitro expression of T helper cytokines. J Rheumatol. 1999; 26:2517-22.</li>
<li>Konrad A, Mähler M, Arni S, et al. Ameliorative effect of IDS30, a stinging nettle leaf extract, on chronic colitis. Int J Colorectal Dis. 2005;20:9-17.</li>
<li>Teucher T, Obertreis B, Ruttkowski T et al. Cytokine secretion in whole blood of healthy subjects following oral administration of Urtica dioica L. plant extract. Arzneimitt. 1996;46:906-10.</li>
<li>Uz T, et al. Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. FASEB J. 1998;12:439-49.</li>
<li>Steele V, et al. Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomarkers Prev. 1999;8:467-83.</li>
<li>South J. America&#8217;s Inflammation Epidemic. The new &#8220;plague&#8221; of our times. Vit Res News. November 2006;20(11). Available online at www.vrp.com.</li>
<li>Neyestani TR, Gharavi A, Kalayi A. Selective effects of tea extract and its phenolic compounds on human peripheral blood mononuclear cell cytokine secretions. Int J Food Sci Nutr. 2009;60 Suppl 1:79-88.</li>
<li>Walsh NE, Ramamurthy S, Schoenfeld L, et al. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil. 1986 Jul;67(7):436-439.</li>
<li>Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105-125.</li>
<li>Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-26.</li>
<li>Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee&#8211;a randomized double blind placebo controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.</li>
<li>Urano T, Ihara H, Umemura K, et al. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001 Jul 6;276(27):24690-24696.</li>
<li>Buford TW, Cooke MB, Redd LL, Hudson GM, Shelmadine BD, Willoughby DS. Protease Supplementation Improves Muscle Function after Eccentric Exercise. Med Sci Sports Exerc. 2009 Sep 2. Published Online Ahead of Print.</li>
<li>Krishnaveni M, Mirunalini S. Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharmacol. 2010;21(1):93-105.</li>
<li>Han Y. Rutin has therapeutic effect on septic arthritis caused by Candida albicans. Int Immunopharmacol. 2009 Feb;9(2):207-11.</li>
<li>Marzani B, Balage M, Vénien A, Astruc T, Papet I, Dardevet D, Mosoni L. Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats. J Nutr. 2008 Nov;138(11):2205-11.</li>
<li>Netti C, Bandi C, Pecile A. Anti-inflammatory action of proteolytic enzymes of animal, vegetable or bacterial origin administered orally compared with that of known antiphlogistic compounds. Il Farmaco. 1972;27:453-466.</li>
</ol>
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		<title>Risk of eating junk foods</title>
		<link>http://carinsmit.co.za/blog/nutrition/risk-of-eating-junk-foods/</link>
		<comments>http://carinsmit.co.za/blog/nutrition/risk-of-eating-junk-foods/#comments</comments>
		<pubDate>Sun, 04 Jul 2010 13:00:31 +0000</pubDate>
		<dc:creator>mafia</dc:creator>
				<category><![CDATA[Nutrition]]></category>

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		<description><![CDATA[(OMNS July 2, 2010) More hot dogs are eaten at the 4th of July holiday than at any other time of the year. The National Hot Dog and Sausage Council (yes, an all-too-real trade organization) says that "during the Independence Day weekend, 155 million will be gobbled up" and that Americans will consume more than seven billion hot dogs over the summer. "Every year," they proudly proclaim, "Americans eat an average of 60 hot dogs each." (1)
]]></description>
			<content:encoded><![CDATA[<p><img src="http://carinsmit.co.za/wp-content/uploads/2010/07/junk_food.jpg" alt="" title="junk_food" width="600" height="300" class="alignnone size-full wp-image-494" /></p>
<div class="page-slide-shadow"></div>
<p><strong>FOR IMMEDIATE   RELEASE</strong> <br />
  <strong>Orthomolecular   Medicine News Service, July 2, 2010</strong> 
</p>
<h3><strong>Pass   the Mustard, or Just Pass on the Hot Dog?</strong></h3>
<p>Comment by   Andrew W. Saul <br />
  Editor-In-Chief, Orthomolecular Medicine News   Service</p>
<p>(OMNS July   2, 2010) More hot dogs are eaten at the 4th of July holiday than at any other   time of the year. The National Hot Dog and Sausage Council (yes, an all-too-real   trade organization) says that &quot;during the Independence Day weekend, 155 million   will be gobbled up&quot; and that Americans will consume more than seven billion hot   dogs over the summer. &quot;Every year,&quot; they proudly proclaim, &quot;Americans eat an   average of 60 hot dogs each.&quot; (<a href="#1">1</a>)</p>
<p>That looks   to be a modest average of just over one hot dog per week per American. But there   are at least 7 million vegetarians in the US, and another 20 million who would   be inclined to avoid meat. (<a href="#2">2</a>)</p>
<p>This means   that even if you do not eat any hot dogs at all, someone else is eating your   share.</p>
<p>But a hot   dog or two a week? Big deal!</p>
<p>Maybe it   is. Children who eat one hot dog a week double their risk of a brain tumor; two   per week triples the risk. Kids eating more than twelve hot dogs a month (three   a week) have nearly ten times the risk of leukemia as children who eat none.   (<a href="#3">3</a>)</p>
<p>And it is   not just about kids. Of 190,000 adults studied for seven years, those eating the   most processed meat such as deli meats and hot dogs had a 68 percent greater   risk of pancreatic cancer than those who ate the least. (<a href="#4">4</a>) Pancreatic cancer is   especially difficult to treat.</p>
<p>Think twice   before you serve up your next tube steak. If your family is going to eat hot   dogs, at least take your vitamins. Hot dog eating children taking supplemental   vitamins were shown to have a reduced risk of cancer. (<a href="#5">5</a>) Vitamins C and E   prevent the formation of nitrosamines. (<a href="#6">6</a>,<a href="#7">7</a>)</p>
<p>It is   curious that, while busy theorizing many &quot;potential&quot; dangers of vitamins, the   news media have largely ignored this clear-cut cancer-prevention benefit from   supplementation.</p>
<p>May I also   suggest that you have your kids chew their hot dogs extra thoroughly. In   landfills, &quot;Whole hot dogs have been found, some of them in strata suggesting an   age upwards of several decades.&quot; (<a href="#8">8</a>)</p>
<p>Bon   appétit.</p>
<hr />
<h2>References:</h2>
<p><a name="1">(1)</a> <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--www.hot-dog.org" target="_blank">http://www.hot-dog.org</a> .</p>
<p><a name="2">(2)</a> <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--www.vegetariantimes.com/features/archive_of_editorial/667" target="_blank">http://www.vegetariantimes.com/features/archive_of_editorial/667</a> .</p>
<p><a name="3">(3)</a> Peters   JM, Preston-Martin S, London SJ, Bowman JD, Buckley JD, Thomas DC. Processed   meats and risk of childhood leukemia. <em>Cancer   Causes Control</em>. 1994 Mar; 5(2):195-202.</p>
<p><a name="4">(4)</a>   Nothlings U, Wilkens LR, Murphy SP, et al. 2005. Meat and fat intake as risk   factors for pancreatic cancer: The Multiethnic Cohort Study. <em>J Nat Cancer Inst</em> 97:1458-65.</p>
<p><a name="5">(5)</a> Sarasua   S, Savitz DA. Cured and broiled meat consumption in relation to childhood   cancer: Denver, Colorado (United States). <em>Cancer Causes Control</em>. 1994 Mar;   5(2):141-8. Comment at <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--www.ralphmoss.com/hotdog.html" target="_blank">http://www.ralphmoss.com/hotdog.html</a> .</p>
<p><a name="6">(6)</a> Scanlan   RA. Nitrosamines and cancer. <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--lpi.oregonstate.edu/f-w00/nitrosamine.html" target="_blank">http://lpi.oregonstate.edu/f-w00/nitrosamine.html</a></p>
<p><a name="7">(7)</a> Cass H;   English J. User&#8217;s guide to vitamin C. Basic Health Publications, 2002, p 64-67.   ISBN-10: 1591200210; ISBN-13: 978-1591200215.</p>
<p><a name="8">(8)</a> <em>Smithsonian</em>, July 1992, p   5.</p>
<p> </p>
<p><strong>Nutritional Medicine is   Orthomolecular Medicine</strong></p>
<p>Orthomolecular medicine uses safe, effective nutritional   therapy to fight illness. For more information: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--www.orthomolecular.org">http://www.orthomolecular.org</a></p>
<p>The   peer-reviewed Orthomolecular Medicine News Service is a non-profit and   non-commercial informational resource.</p>
<p> </p>
<p><strong>Editorial Review   Board:</strong></p>
<p>Ralph K.   Campbell, M.D. (USA) <br />
  Carolyn Dean, M.D., N.D. (Canada) <br />
  Damien Downing,   M.D. (United Kingdom) <br />
  Michael Ellis, M.D. (Australia) <br />
  Michael Gonzalez,   D.Sc., Ph.D. (Puerto Rico) <br />
  Steve Hickey, Ph.D. (United Kingdom) <br />
  James A.   Jackson, Ph.D. (USA) <br />
  Bo H. Jonsson, M.D., Ph.D. (Sweden) <br />
  Thomas Levy,   M.D., J.D. (USA) <br />
  Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico) <br />
  Erik   Paterson, M.D. (Canada) <br />
  Gert E. Shuitemaker, Ph.D.   (Netherlands)</p>
<p><strong>Andrew W. Saul, Ph.D. (USA), Editor   and contact person. Email: <a href="mailto:omns@orthomolecular.org">omns@orthomolecular.org</a></strong></p>
<p><strong>To Subscribe at no   charge:</strong> <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=86&amp;e=MTYxNjA=&amp;l=-http--www.orthomolecular.org/subscribe.html" target="_blank">http://www.orthomolecular.org/subscribe.html</a></p>
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		<title>Vitamin C and Cardiovascular Disease</title>
		<link>http://carinsmit.co.za/blog/nutrition/vitamin-c-and-cardiovascular-disease/</link>
		<comments>http://carinsmit.co.za/blog/nutrition/vitamin-c-and-cardiovascular-disease/#comments</comments>
		<pubDate>Mon, 28 Jun 2010 18:31:14 +0000</pubDate>
		<dc:creator>mafia</dc:creator>
				<category><![CDATA[Nutrition]]></category>

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		<description><![CDATA[Critical value of high dose vitamin C for humans]]></description>
			<content:encoded><![CDATA[<p><img src="http://carinsmit.co.za/wp-content/uploads/2010/06/vitaminC.jpg" alt="vitamin C" title="vitaminC" width="600" height="300" class="alignnone size-full wp-image-496" /></p>
<div class="page-slide-shadow"></div>
<p><strong>FOR IMMEDIATE RELEASE</strong> <br />
  <strong>Orthomolecular Medicine News Service, June 22,   2010</strong> 
</p>
<h2><strong>Vitamin C and Cardiovascular   Disease<br />
</strong>A   Personal Viewpoint by Alan Spencer and Andrew W.   Saul</h2>
<p>(OMNS, June   22, 2010) Linus Pauling was aware that studies of the animal kingdom showed that   most animals have the ability to manufacture vitamin C in their bodies. Humans   cannot. Furthermore, on average, mammals make 5,400mg daily when adjusted for   body weight, and make more (often considerably more) when under stress or ill.   This is about 100 times as much as the 50mg we get from a typical modern diet.   It prompts the question, why do animals make so much vitamin C, and what purpose   does it serve in the body?</p>
<p>A small   number of animals which are known to share our inability to make vitamin C   include the apes, the guinea pig, the fruit bat, and some birds, all of which   will normally get a lot of vitamin C from their food. If you deprive a guinea   pig of vitamin C it soon develops a form of cardiovascular disease (damage to   its arteries showing within a few weeks). Similarly, studies of genetically   modified mice have shown that if you switch off the gene that enables a mouse to   produce vitamin C it will also soon show signs of heart disease. Re-introduction   of a high vitamin C diet enables the damage to be reversed. While heart disease   is rare in the animal kingdom, it is becoming a problem for apes in zoos where   their diets are perhaps not as rich in vitamin C as when they are in the   wild.</p>
<p><strong>Collagen</strong> <br />
  A very   important function of vitamin C in the body is its role in the production of   collagen. Collagen is the most abundant protein in the body, and forms into   fibres which are stronger than iron wire of comparable size. These fibres   provide strength and stability to all body tissues, including the arteries.   Vitamin C is absolutely essential for the production and repair of collagen, and   is destroyed during the process, so a regular supply of vitamin C is necessary   to maintain the strength of body tissues. Severe deficiency of vitamin C causes   the total breakdown of body tissue witnessed in scurvy. Linus Pauling believed   that whilst humans normally obtain sufficient vitamin C to prevent full-blown   scurvy, we do not consume enough to maintain the strength of the walls of the   arteries. He suggested that of all the structural tissues in the body, the walls   of the arteries around the heart are subject to the greatest continual stress.   Every time the heart beat s the arteries are flattened and stretched, and this   has been likened to standing on a garden hose thousands of times a day. Many   tiny cracks and lesions develop and the artery walls become   inflamed.</p>
<p>Dr. Pauling   believed that in the presence of adequate supplies of vitamin C this damage can   be readily repaired and heart disease is avoided. However, in the absence of   adequate levels of vitamin C, the body attempts to repair the arteries using   alternative materials: cholesterol and other fatty substances, which attach to   the artery wall. (1-8)</p>
<p><strong>Cholesterol and Lipoprotein (a),   Lp(a)</strong> <br />
  The most abundant amino acids (protein building   blocks) in collagen are lysine and proline, and when collagen strands are   damaged lysine and proline become exposed. A special kind of cholesterol,   lipoprotein(a), is attracted to lysine and proline and will attach itself to the   exposed damaged collagen strands. It is an attempt by the body to repair damage   to the collagen of the artery walls in the absence of adequate levels of vitamin   C. Unfortunately the repair is not ideal and over many years repeated deposits   can cause the artery to become narrow and inflamed. Heart attack or stroke is   likely to follow (usually caused by a clot forming at the site of the narrowed   artery, or by a piece of plaque breaking off and blocking a smaller vessel   downstream). When vitamin C levels are low, the body manufactures more   cholesterol, especially Lp(a). Conversely, when vitamin C levels are high the   body makes less cholesterol.</p>
<p>If high   blood cholesterol were the primary cause of heart disease, all bears and other   hibernating animals would have become extinct long ago. They naturally have high   cholesterol levels. One reason bears are still with us is simple: they produce   large amounts of vitamin C in their bodies, which stabilises the artery walls,   and there is therefore no tendency to develop cholesterol deposits or   plaque.</p>
<p><strong>Keeping healthy</strong> <br />
  The low levels of vitamin C that are available through diet are inadequate   to prevent many people developing arterial plaques, and over time this may   result in cardiovascular disease. Post mortem examinations showed that 77% of   young American soldiers killed in the Korean war (average age 22) already had   well-advanced atherosclerosis (heart disease), and post mortem studies from the   Vietnam war gave similar results. Heart disease is not just a disease of the   elderly, although it does not usually become life threatening until later in   life.</p>
<p>How can we   prevent it? Pauling believed that once we start taking high levels of vitamin C,   the disease process is halted, or at least slowed, as Lp(a) cholesterol is no   longer needed as a repair material. He also believed that when we take adequate   levels of vitamin C, existing arterial plaques may start to be removed from the   arteries. He found that the removal of plaques is more rapid if the amino acid   lysine is taken along with vitamin C. Lysine appears to attach to the Lp(a) in   existing plaque deposits and helps to loosen them. Linus Pauling recommended at   least 3000mg of vitamin C per day as a preventive dose, and significantly higher   levels of both vitamin C and lysine for the treatment of existing heart disease.   Dosage is a key factor: low doses are ineffective.</p>
<p><strong>Retention in the   body</strong> <br />
  Another important point is that a single dose of   vitamin C is not retained in the body for very long. This fact has been used for   a long time by those who do not support the use of high doses of vitamin C as   evidence that the body does not need and cannot use large doses. After a single   large dose of vitamin C, the blood level quite soon returns to a low level. A   lot is excreted, the high blood level only remaining for a few   hours.</p>
<p>The key   factor here is that the body is not designed to function with just a single   large dose of vitamin C once a day. Animals are able to manufacture vitamin C in   their bodies and do so continuously throughout the day. They have an enzyme   which converts glucose to vitamin C, and each day they produce on the order of a   hundred times more vitamin C than we are able to get from even a good diet. When   animals are ill they manufacture even more, perhaps thousands of times more than   we can get from our diet.</p>
<p><strong>How much should we   take?</strong> <br />
  For people who are essentially fit and well, the   Vitamin C Foundation recommends perhaps 3,000mg of vitamin C per day, taken in   divided doses as 500mg every four hours, as a protection against the development   of heart disease. The problem with even this protective dose is that taking a   tablet every four hours is not something that many people would want to adopt as   part of their daily routine. But there is good evidence to suggest that this   level of intake will help maintain the strength of the arteries and prevent the   build up of cholesterol plaques. If everybody were to do this, perhaps heart   disease would become a largely a thing of the past (as might many other chronic   diseases).</p>
<p>When   treating illness, &quot;bowel tolerance&quot; is the indicator of dosage level that should   be used. This means taking just under the level of vitamin C (in divided doses)   that results in loose stools. Everyone is different. Note that while a few   1,000mg doses a day might make you loose when you are fit and well, your &quot;bowel   tolerance&quot; might increase to ten or even a hundred times this when very ill. So,   for illness, the levels suggested by the Vitamin C Foundation are 6,000mg to   18,000mg of vitamin C per day (or up to bowel tolerance) plus 2,000mg to 6,000mg   of lysine. These vitamin C levels may seem high, but are perhaps not   particularly large when compared with levels seen in the animal kingdom. A   substantial amount of lysine may be obtained from diet. For example, one may   obtain 3,000 to 4,000 milligrams of lysine from about can and a half of beans.   Supplementation reduces the need to consume that   much.</p>
<p><strong>Controversy</strong> <br />
  <em>&quot;Even though some physicians had   observed forty or fifty years ago that amounts of vitamin C a hundred to a   thousand times larger (than the RDA) have value in controlling various diseases,   the medical profession and most scientists ignored this evidence.&quot;</em> (Linus Pauling, <em>How to Live Longer and Feel   Better</em>)</p>
<p>In medical   circles, Pauling&#8217;s recommendations remain controversial. However, his theory   seems reasonable, and the implications are so significant that some major   scientific trials should have been undertaken to assess it. This has not   happened. Supporters of high-dose vitamin C have had their applications for   research funding denied repeatedly, and have had to be content with carrying out   small scale research projects and case studies. These have been very positive.   Over the past fifteen years, Pauling therapy advocates have received hundreds of   reports from heart patients who have self administered the therapy. It is   reported that these people typically recover within 30 days, and the majority   experience significant relief within as little as a week or two. In 1994, Linus   Pauling wrote, &quot;I think we can get almost complete control of cardiovascular   disease, heart attacks and strokes by the proper use of vitamin C and lysine. It   can prevent cardiova scular disease and even cure it. If you are at risk of   heart disease, or if there is a history of heart disease in your family, if your   father or other members of the family died of a heart attack or stroke or   whatever, or if you have a mild heart attack yourself, then you had better be   taking vitamin C and lysine.&quot;</p>
<hr />
<h2>References:</h2>
<p> (1) Rath   M, Pauling L. Immunological evidence for the accumulation of lipoprotein(a) in   the atherosclerotic lesion of the hypoascorbemic guinea pig. Proc Natl Acad Sci   U S A. 1990 Dec;87(23):9388-90. PMID: 2147514. Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.pnas.org/content/87/23/9388.full.pdf" target="_blank">http://www.pnas.org/content/87/23/9388.full.pdf</a></p>
<p>(2) Rath M,   Pauling L. Hypothesis: lipoprotein(a) is a surrogate for ascorbate. Proc Natl   Acad Sci U S A. 1990 Aug;87(16):6204-7. [Erratum in: Proc Natl Acad Sci U S A   1991 Dec 5;88(24):11588.] PMID: 2143582. Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.pnas.org/content/87/16/6204.full.pdf" target="_blank">http://www.pnas.org/content/87/16/6204.full.pdf</a></p>
<p>(3) Rath M,   Pauling L. Solution To the Puzzle of Human Cardiovascular Disease: Its Primary   Cause Is Ascorbate Deficiency Leading to the Deposition of Lipoprotein(a) and   Fibrinogen/Fibrin in the Vascular Wall. J Orthomolecular Med, Vol 6, 3&amp;4th   Quarters, 1991, p 125. Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1991/pdf/1991-v06n03--A-04-p125.pdf" target="_blank">http://orthomolecular.org/library/jom/1991/pdf/1991-v06n03&amp;04-p125.pdf</a></p>
<p>(4) Pauling   L, Rath M. An Orthomolecular Theory of Human Health and Disease. J   Orthomolecular Med, Vol 6, 3&amp;4th Quarters, 1991, p 135. Free full text   download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1991/pdf/1991-v06n03--A-04-p135.pdf" target="_blank">http://orthomolecular.org/library/jom/1991/pdf/1991-v06n03&amp;04-p135.pdf</a></p>
<p>(5) Rath M,   Pauling L. Apoprotein(a) Is An Adhesive Protein. J Orthomolecular Med, Vol 6,   3&amp;4th Quarters, 1991, p 139. Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1991/pdf/1991-v06n03--A-04-p139.pdf" target="_blank">http://orthomolecular.org/library/jom/1991/pdf/1991-v06n03&amp;04-p139.pdf</a></p>
<p>(6) Rath M,   Pauling L. Case Report: Lysine/Ascorbate Related Amelioration of Angina   Pectoris. J Orthomolecular Med, Vol 6, 3&amp;4th Quarters, 1991, p 144. Free   full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1991/pdf/1991-v06n03--A-04-p144.pdf" target="_blank">http://orthomolecular.org/library/jom/1991/pdf/1991-v06n03&amp;04-p144.pdf</a></p>
<p>(7) Rath M,   Pauling L. A Unified theory of Human Cardiovascular Disease Leading the Way To   the Abolition of This Diseases As A Cause for Human Mortality. J Orthomolecular   Med, Vol 7, First Quarter 1992, p 5. Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf" target="_blank">http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p005.pdf</a></p>
<p>(8) Rath M,   Pauling L. Plasmin-induced Proteolysis and the Role of Apoprotein(a), Lysine and   Synthetic Lysine Analogs. J Orthomolecular Med, Vol 7, First Quarter 1992, p 17.   Free full text download: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p017.pdf" target="_blank">http://orthomolecular.org/library/jom/1992/pdf/1992-v07n01-p017.pdf</a></p>
<hr />
<h2>For More   Information:</h2>
<p>Fonorow O.   Practicing Medicine Without a License? The Story of the Linus Pauling Therapy   for Heart Disease. 2008. Lulu.com. ISBN-10: 1435712935; ISBN-13: 978-1435712935.   Reviewed in J Orthomolecular Med, 2009. Vol 24, No 1, p   51-5.</p>
<p>Hickey S   and Roberts H. Ascorbate: The Science of Vitamin C. 2004. ISBN-10: 1411607244;   ISBN-13: 978-1411607248. Lulu.com. This book contains 575 references, and is   reviewed at <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.doctoryourself.com/ascorbate.html" target="_blank">http://www.doctoryourself.com/ascorbate.html</a></p>
<p>Hickey S,   Saul AW. Vitamin C: The Real Story. Laguna Beach, CA: Basic Health Publications,   2008. ISBN: 978-1-59120-223-3. This book contains 387 references, and is   reviewed at <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.doctoryourself.com/realstory.html" target="_blank">http://www.doctoryourself.com/realstory.html</a></p>
<p>Levy TE.   Stop America&#8217;s #1 Killer: Reversible vitamin deficiency found to be the origin   of all coronary heart disease. 2006. ISBN-10: 0977952002; ISBN-13:   978-0977952007. (Dr. Levy is a board-certified cardiologist.) Reviewed in J   Orthomolecular Med, 2006. Vol 21, No 3, p 177-178. This book contains 60 pages   of references. To download the review: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/2006/pdf/2006-v21n03-p175.pdf" target="_blank">http://orthomolecular.org/library/jom/2006/pdf/2006-v21n03-p175.pdf</a></p>
<p>Pauling L.   How to Live Longer and Feel Better (Revised edition). Oregon State University   Press, 2006. ISBN-10: 0870710966; ISBN-13: 978-0870710964. Reviewed in J   Orthomolecular Med, 2006. Vol 21, No 3, p 175-177. To download the review: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/library/jom/2006/pdf/2006-v21n03-p175.pdf" target="_blank">http://orthomolecular.org/library/jom/2006/pdf/2006-v21n03-p175.pdf</a></p>
<p><strong>On the   Web:</strong></p>
<p>The Vitamin   C Foundation <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.vitamincfoundation.org" target="_blank">http://www.vitamincfoundation.org</a></p>
<p>AscorbateWeb, a historical compendium of 20th-Century   medical and scientific literature demonstrating the efficacy of vitamin C. <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.seanet.com/~alexs/ascorbate/" target="_blank">http://www.seanet.com/~alexs/ascorbate/</a></p>
<p>Putting the   &quot;C&quot; in Cure: Quantity and frequency are the keys to ascorbate therapy. <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/resources/omns/v05n11.shtml" target="_blank">http://orthomolecular.org/resources/omns/v05n11.shtml</a></p>
<p>Vitamin C   Saves Lives. <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/resources/omns/v01n02.shtml" target="_blank">http://orthomolecular.org/resources/omns/v01n02.shtml</a></p>
<p>RDA for   Vitamin C is 10% of USDA Standard for Guinea Pigs. <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/resources/omns/v06n08.shtml" target="_blank">http://orthomolecular.org/resources/omns/v06n08.shtml</a></p>
<p>Vitamin C:   What Form is Best? <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--orthomolecular.org/resources/omns/v05n10.shtml" target="_blank">http://orthomolecular.org/resources/omns/v05n10.shtml</a></p>
<p><strong>Nutritional Medicine is   Orthomolecular Medicine</strong></p>
<p>Orthomolecular medicine uses safe, effective nutritional   therapy to fight illness. For more information: <a href="http://www.cihfimediaservices.org/12all/lt/t_go.php?i=83&amp;e=MTYxNjA=&amp;l=-http--www.orthomolecular.org">http://www.orthomolecular.org</a></p>
<p>The   peer-reviewed Orthomolecular Medicine News Service is a non-profit and   non-commercial informational resource.</p>
<p> </p>
<p><strong>Editorial Review   Board:</strong></p>
<p>Ralph K.   Campbell, M.D. (USA) <br />
  Carolyn Dean, M.D., N.D. (Canada) <br />
  Damien Downing,   M.D. (United Kingdom) <br />
  Michael Ellis, M.D. (Australia) <br />
  Michael Gonzalez,   D.Sc., Ph.D. (Puerto Rico) <br />
  Steve Hickey, Ph.D. (United Kingdom) <br />
  James A.   Jackson, Ph.D. (USA) <br />
  Bo H. Jonsson, M.D., Ph.D. (Sweden) <br />
  Thomas Levy,   M.D., J.D. (USA) <br />
  Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico) <br />
  Erik   Paterson, M.D. (Canada) <br />
  Gert E. Shuitemaker, Ph.D.   (Netherlands)</p>
<p><strong>Andrew W. Saul, Ph.D. (USA), Editor   and contact person. Email: <a href="mailto:omns@orthomolecular.org">omns@orthomolecular.org</a></strong></p>
<p>This article is &copy; <a href="http://www.orthomolecular.org">www.orthomolecular.org</a> and has been republished with permission.</p>
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		<title>Dietary Changes can make a difference&#8230;</title>
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		<pubDate>Tue, 23 Mar 2010 05:37:20 +0000</pubDate>
		<dc:creator>mafia</dc:creator>
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		<description><![CDATA[The question I'm most frequently asked: "Can diet REALLY make such a difference?"  The simple answer is: Yes it can! 

What is THE DIET I'm referring to? It is a gluten-free, casein-free, gliadin-free diet. I instruct those with significant health problems who see me to take all grains, dairy, legumes, nuts, seeds and pulses out of their diets. ]]></description>
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<p>The question I&#8217;m most frequently asked: &#8220;Can diet REALLY make such a difference?&#8221;  The simple answer is: Yes it can!</p>
<p>What is THE DIET I&#8217;m referring to? It is a gluten-free, casein-free, gliadin-free diet. I instruct those with significant health problems who see me to take all grains, dairy, legumes, nuts, seeds and pulses out of their diets.</p>
<p>The nett result? No more allergies, no more asthma, eczema gone, IBS gone, no more constipation, no more diarrhoea, children who are autistic stop bizarre behaviours and start speaking, children and adults with sleeping problems start sleeping though. Others lose weight, say their blood pressure problems have diminished or disappeared, their cancers are receding and their depression has lifted. Schizophrenics move back into reality and those with bi-polar disorders regain control over their lives&#8230;.</p>
<p>So, in short, does it work? It most certainly does and I am delighted to be the recipient of the many, many good-news stories!</p>
<p>Please feel free to either share your story or post your comments/questions and let&#8217;s get the ball rolling in discussing this crucial and life-changing intervention.</p>
<p>And oh, <em>what CAN you eat?</em> All meat, chicken, eggs, vegetables (except beans of any kind, which includes coffee beans, cocao beans, broad beans, soya beans, lupine beans, baked beans, peas, lentils, chickpeas) and fruit. I allow corn, sorghum and brown rice and for those who do not have thyroid problems, I allow millet once or twice a week, as millet is a thyroid disrupter.</p>
<p>Many people are worried that they won&#8217;t get full on a low carbohydrate diet &#8211; I allow potatoes, sweet potatoes (yams), butternut, pumpkin, turnips, parsnips, squashes, banana and as I said above corn, brown rice and sorghum, with the odd day&#8217;s millet.</p>
<p>These diets are NOT nutrient poor, in fact, they are VERY COMPREHENSIVE, but need management, such as ensuring that super-nutrition (*my phrase which means nutrients given in addition or above food intake*) is carefully monitored. Here I think of at least the RDA of Calcium, Magnesium, B-Complex and some Vitamin C in high doses.</p>
<p>Fish is totally out, unless you can see it&#8217;s head and tail on the palm of your hand and even then don&#8217;t consume more than 1x per week.</p>
<p>I always ask people to drop the deadly (white) killer, sugar, from their diets and start reading labels &#8211; all that sucrose, maltose, lactose, fructose, and what-ever other -ose they can hide in our foods &#8211; please stay away from these. Honey, loved and touted by many as a healing compound, can cause intestinal disruption, so use sparingly, if at all. Some of you just simply CAN&#8217;T use honey, as it&#8217;s glucose content is HIGH and your glucose metabolism is poor.</p>
<p>I hope these initial few comments help set the scene for an excellent discussion. If you have questions we can&#8217;t manage on this forum, please feel free to book a consultation at Johannesburg office. Tel. 011-760-2951.</p>
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